As benzothiazole has proven to be good antimicrobial agent, in the present study Benzothiazoles has been chosen as basic nucleus. The nucleus was reacted with p-nitro benzoyl chloride in the presence of TEA and 1,4 dioxane to obtain N-(6- fluorobenzo[d] thiazol-2-yl)-4-nitrobenzamide, which was subjected to reduction by Fe/ Hcl to obtain N-(6- fluorobenzo[d] thiazol-2-yl)-4-aminobenzamide. This product contains active site (-NH2) from which one water molecule was lost and Schiff bases were prepared by using various substituted benzaldehydes. Their purity and homogeneity were confirmed from their sharp physical constants and Rf values. All the Schiff bases were obtained in solid form with excellent yield. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data. All the synthesized compounds were screened for their antitubercular and antibacterial activity.
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